、？
How would you like your meat cooked?
Literal
[honorific-お]meat [of-の] cooked-degree [topic-は], how [honorific-なさる]?
Restaurant/server keigo. 焼き加減 = 'degree of cooking' (for meat: rare, medium, well done). お is a polite beautifier on 肉. いかがなさいますか combines いかが ('how,' polite) + なさる ('to do,' sonkeigo of する) + ます polite ending — the standard high-register server's question. 加減 attached to verb stems productively creates 'degree/level of X-ing' compounds.