夫(ふ)妻(さい) fusaiは wa化(か)学(がく) kagakuを o近(きん)代(だい)科(か)学(がく) kindaikagakuへと heto一(いっ)変(ぺん) ippenさせた saseta。 The couple transformed chemistry into a modern science. Literal Husband-and-wife [topic-は] chemistry [object-を] modern-science [toward-へと] completely-changed. 一変させた is the causative of 一変する ('to change completely'): 'made it change completely.' へと combines direction へ with the quotative/resultative と. Likely refers to the Curies or Lavoisiers. historysciencemarriagecausative form (~せる/~させる)
夫(ふ)妻(さい) fusaiは wa化(か)学(がく) kagakuを o近(きん)代(だい)科(か)学(がく) kindaikagakuへと heto一(いっ)変(ぺん) ippenさせた saseta。 The couple transformed chemistry into a modern science. Literal Husband-and-wife [topic-は] chemistry [object-を] modern-science [toward-へと] completely-changed. 一変させた is the causative of 一変する ('to change completely'): 'made it change completely.' へと combines direction へ with the quotative/resultative と. Likely refers to the Curies or Lavoisiers. historysciencemarriagecausative form (~せる/~させる)