It's handy to know how to use spreadsheet software.

Literal

Spreadsheet-software [topic-は] remembering [conditional-と] something-or-other convenient [feminine-よ].

覚えておくと何かと便利 — ておくと uses ておく ('learn in advance') with the conditional と. 何かと means 'in various ways.' The sentence-final よ has a feminine/gentle tone. 表計算ソフト is the Japanese term for spreadsheet software.