Make sure to pick me up by car at five o'clock.

Literal

Certainly 5-o'clock [at-に] car [by-で] me [object-を] picking-up coming [manner-するようにしてください].

迎えに来るようにしてください — 迎えに来る means 'come to pick up,' and ようにする means 'make sure to.' The layered request is very thorough.