If you're tired, studying is pointless.

Literal

Tired [if-のなら] studied [even if-って] useless [masculine-ぞ].

~のなら is a conditional: 'if it's the case that.' ~たって is a casual concessive meaning 'even if.' 無駄だ means 'useless, pointless.' ぞ is a forceful masculine sentence-final particle.