She is holding a rose in her hand.

Literal

She [topic-は] rose [object-を] hand [in-に] is-holding.

薔薇 (ばら, 'rose') is typically written in katakana (バラ) or hiragana because the kanji are notoriously complex — seeing them in full kanji form demonstrates the existence of difficult characters for common words. 手に持っている uses に to mark the body part where the holding occurs.