She's from Hokkaido, but she lives in Tokyo now.

Literal

She [topic-は] Hokkaido origin [but-が], now [contrast-は] Tokyo [in-に] is-living.

A clean example of contrastive は — 今は ('as for now') contrasts her current situation with her origin. 出身 ('origin/birthplace') is a common compound for stating where someone is from.