In the end, everyone has no choice but to learn on their own.
Literal
In-the-end [topic-は] anyone [even-でも] self [by-で] learn only [no choice-しかない].
結局は 'in the end, ultimately' — a common discourse marker for conclusions. ~しかない 'there's nothing but, no choice but to' expresses resignation to the only available option. 自分で学ぶ 'to learn by oneself' — 自分で marks the agent of self-directed action.