。
She inquired after his safety.
Literal
She [topic-は] his [genitive-の] safety [object-を] inquired.
安否 ('safety, well-being,' literally 'safe-or-not') is a Sino-Japanese compound that captures the question itself — 'is he safe or not?' Used especially after disasters, accidents, or absences when whereabouts and well-being are uncertain. 安否を尋ねる is a near-set collocation. 安否を確認する ('confirm safety') is similarly common.