、。
Despite her efforts, she didn't succeed.
Literal
She [topic-は] effort did [despite-にもかかわらず], did-not-succeed.
~にもかかわらず is a formal concessive meaning 'despite / in spite of' — heavier and more literary than ~のに or ~けど. It emphasizes the contradiction between effort and outcome. 努力する (to make effort) and 成功する (to succeed) are both common Sino-Japanese compound verbs that pair naturally in discussions of achievement.