。
She devoted her life to helping people with physical disabilities.
Literal
She [topic-は] physically-disabled-people [object-を] helping [nominalizer-こと] [to-に] life [object-を] devoted.
身体障害者 (しんたいしょうがいしゃ) is the formal term for 'person with a physical disability,' a three-part compound: 身体 ('body') + 障害 ('impairment') + 者 ('person'). The verb 捧げる (ささげる, 'to dedicate, to devote') carries an elevated, almost solemn tone — stronger and more self-sacrificing than 費やす ('to spend'). The ~ことに structure nominalizes the purpose clause and marks it with に as the target of her devotion.