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I'm utterly fed up with no-show cancellations.
Literal
Unauthorized-cancellation [to-に][topic-は] utterly troubled.
無断キャンセル 'no-show cancellation, canceling without notice.' ほとほと 'utterly, thoroughly, to the point of exhaustion' — an expressive adverb for being fed up. 困っています 'am troubled by' in polite progressive. A business owner's or service provider's complaint.