。
She shielded her eyes from the sunlight with her hand.
Literal
She [topic-は] hand [with-で] eyes [from-から] sunlight [object-を] blocked.
手で (with one's hand) uses the instrumental で for the tool used. 目から日差しを遮る literally means 'to block sunlight from (reaching) the eyes' — から marks what the sunlight is being kept away from. 遮る (さえぎる) means to block, obstruct, or intercept. A vivid physical scene of someone squinting against bright light.