。
She can't drive a car.
Literal
She [topic-は] car [of-の] driving [subject-が] cannot-do.
運転ができない uses the potential negative of できる — she lacks the ability to drive. 車の運転 (driving of a car) treats driving as a noun phrase, then が marks it as the subject of できない. The construction frames inability as something the person 'doesn't have access to,' rather than a skill they 'can't perform' (運転できない would be the leaner verbal alternative). In Japan, where most people drive only after passing a fairly demanding licensing process, 'can't drive' often means 'never got a license' rather than 'doesn't know how to operate a car.'