She should be charged with murder.

Literal

She [topic-は] murder-crime [target-に] be-questioned should.

罪に問われる ('be charged with a crime, be held accountable for') is a fixed legal collocation built from 罪 ('crime, sin') + 問われる, the passive of 問う ('to question, ask, hold to account'). The kanji 問 carries the legal sense of 'examine, hold answerable to.' The auxiliary べき ('should, ought to') closes the sentence as a moral-legal recommendation. 殺人罪 ('crime of murder') compounds 殺人 ('murder') + 罪. A sentence that fits naturally in legal commentary or news reporting.