。
She should be home by now.
Literal
She [topic-は] around-this-time house [at-に] is-arrived [supposed-to-はず] is.
着く ('to arrive') takes the destination with に — 家に ('home') marks where she's expected to land. The combination 着いている ('is in arrived state') is the natural way to express 'has arrived and remains there' — Japanese turns the punctual event of arrival into a stable resulting state via ~ている. ~はず adds the speaker's reasoned expectation: based on travel time and circumstances, she should be home now.