。
She's worried sick about whether you're okay, you know.
Literal
She [topic-は] your safety/well-being [object-を] is-being-concerned [you know-よ].
安否 ('safety/well-being') is a compact noun that literally means 'safe or not' (安 'safe' + 否 'not') — the kind of wholesale either-or formed by 漢語 compounds for Japanese to package whole questions into a single noun. It's heavier than just 'health' — it connotes worry about someone's life and welfare during a crisis, illness, or extended silence. 気遣う ('to be concerned about, attend to') is gentler than 心配する: it implies thoughtful care and attentive consideration, not anxious distress.