。
She was born and raised in the old downtown.
Literal
She [topic-は] shitamachi [in-で] was-born-raised.
下町 ('lower town') refers to the older, working-class neighborhoods of Edo (now Tokyo) — the flat lowlands along the rivers and bay where merchants and artisans lived, in contrast to the elevated 山の手 ('uptown') residential districts of the samurai class. The term is loaded with cultural connotations: warmth, neighborliness, traditional craft, and a slightly nostalgic plain-speaking charm. 生まれ育つ is a tightly fused compound verb ('be-born and grow-up'), conventional shorthand for one's origin and upbringing.