She is a very beautiful woman.

Literal

She [topic-は] very beautiful person is.

美しい is the more literary register for 'beautiful' compared to the everyday きれい. It carries an aesthetic, almost reverent feel — at home in poetry, descriptions of art, and formal compliments. Of a person it suggests classical, refined beauty rather than cute or stylish. Reserve きれい for everyday compliments; save 美しい for moments worth the gravitas.