肥大化、過度の商業化などの問題も抱えて、五輪は新世紀に向かう。

、、。

The Olympics head into the new century carrying problems like bloating and excessive commercialization.

Literal

Enlargement, excessive commercialization [and-など] [possessive-の] problems [also-も] holding, Olympics [topic-は] new-century [toward-に] head.

肥大化 ('enlargement, bloating') and 過度の商業化 ('excessive commercialization') are the named problems. ~など marks them as examples from a longer list. 抱えて ('holding, carrying') is the key metaphor — the Olympics carry these problems as burdens. 新世紀に向かう ('heading toward the new century') frames the temporal direction. A news editorial sentence.