She wept bitterly.

Literal

She [topic-は] bitterly cried.

さめざめ is a state mimetic (擬態語) for quiet, sustained, bitter weeping — tears flowing in silence rather than loud sobs. A literary, evocative word: you're more likely to encounter it in fiction or poetry than in casual conversation, where しくしく (soft sniffling) or わんわん (loud crying) might fit better. The と attaches it to 泣いた as an adverbial mimetic — a standard frame for fitting mimetic adverbs into sentences. Captures a specific kind of grief: composed on the surface but inwardly devastated.