。
She can't operate this machine.
Literal
She [topic-は] this machine [object-を] cannot-operate.
動かす ('to move, operate') is the transitive partner of 動く ('to move' intransitive); 動かせない is its potential negative — 'cannot operate.' Japanese has matched transitive/intransitive verb pairs as a structural feature: 動く/動かす, 出る/出す, 開く/開ける, 始まる/始める. Knowing both halves of the pair is essential for natural Japanese. 機械 ('machine, mechanism') is a common Sino-Japanese compound. The whole sentence is the kind of complaint or admission you'd make in an office or factory.