。
He's a handsome leading man.
Literal
He [topic-は] second-poster [copula-だ].
二枚目 (にまいめ, 'second poster') is a kabuki term: theater billboards listed roles in order — the second poster was always the romantic lead, the handsome one. In modern use, it simply means 'handsome man' or 'leading man type.' The cultural etymology makes this a great vocabulary item for learners interested in Japanese theater history.