、！！
Ugh, I can't focus on studying at all!!
Literal
Geez, completely studying [subject-が] hand [to-に] not-reach [feminine-わよっ]!!
手につかない ('can't get one's hands on, can't focus on') is an idiom for inability to concentrate. The final わよっ stacks feminine わ with assertive よ and a small 促音 っ (glottal-stop clipping) for emphatic, frustrated delivery — a delivery pattern often heard in tsundere-style speech. 全然...ない ('not at all') is the total negation pattern. The double exclamation marks and もうっ convey peak frustration.