？
How ya doin'? Feeling refreshed the morning after losing your virginity?
Literal
How-ya? Virgin graduate-did next-morning [topic-は] mood-refreshed?
どーお is the spoken slurring of どう (often written どー for drawn-out casual speech). 童貞 'virginity' (male, specifically) is the counterpart of 処女 (female). 卒業 'graduation' is used idiomatically for 'losing (one's virginity)' — extending the academic metaphor to life milestones. 気分爽快 is a 四字熟語 for 'feeling refreshed / clear-headed / in high spirits' — often used after a bath, a good night's sleep, or exercise.