Just reading the computer manual is, at the end of the day, nothing more than practicing swimming on a tatami mat.

Literal

Computer [gen-の] manual [obj-を] read-only [with-では] after-all tatami [gen-の] top [gen-の] swimming-practice [copula-だ].

Built around the proverb 畳の上の水練 — literally 'swimming practice on a tatami mat,' meaning useless book-learning divorced from actual practice. 所詮 'after all / in the end' is an adverb with a resigned, dismissive tone, often framing something as ultimately futile. ~だけでは 'just by X alone' sets up the insufficient condition.