。
The train runs nonstop to Nagoya.
Literal
Train [topic-は] Nagoya [until-まで] nonstop [instrumental-で] runs.
まで marks the end-point ('all the way to Nagoya') and で marks the manner/instrument ('in nonstop fashion'). ノンストップ is an English loanword used as a な-adjective or adverbial noun. 走ります is the polite form of 走る — trains 'run' in Japanese just as in English.