。
The train doesn't stop at that station.
Literal
Train [topic-は] that station [at-では] does-not-stop.
では is the composite で + は: the で marks location ('at that station'), the は adds contrastive focus ('at that station specifically, (as opposed to others) it doesn't stop'). Without the は it would read as a neutral negative; with the は it implies the train does stop at other stations.