。
As usual, she didn't show up on time.
Literal
Example [by-によって] she [topic-は] again on-time [topic-には] did-not-appear.
またしても~なかった emphasizes a recurring failure — 'yet again she didn't.' 現われる ('to appear, show up') + 時間通りには where は adds contrastive focus ('on time specifically, as opposed to at all'). A pointed complaint about someone's reliability.