My neighbors are four sisters and one cat.

Literal

Neighbors [topic-は] 4-people sisters [and-と] cat 1-animal [copula-です].

Counters: 4人 for people and 1匹 for small animals (cats, dogs, fish, insects). 姉妹 ('sisters') — the compound noun joining 姉 (older sister) and 妹 (younger sister). A charming quotable sentence — the specific inclusion of the cat gives it personality.