The neighbor's radio is driving me crazy — it's so loud.
Literal
Next [of-の] house [of-の] radio [subject-が] is-noisy-ていらいら do.
いらいら is a mimetic (擬態語) for the state of frustration, irritation, or impatience. Paired with する, it becomes the verb 'to be irritated, feel impatient.' The て-form うるさくて chains the reason (the noise) to the irritation (いらいらする). Vivid daily-life complaint.