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Hold the vase with both hands.
Literal
Both-hands [with-で] that vase [object-を] hold [command-なさい].
花びん (flower vase) is a transparent compound: 花 (flower) + びん (bottle/vessel). 両手で marks the means — 'with both hands.' A practical instruction about handling fragile objects, the kind a parent or teacher would give a child.