旅客機のパイロットは乗客の安全に対し責任がある。

。

The pilot of a passenger plane is responsible for the safety of the passengers.

Literal

Passenger-plane [possessive-の] pilot [topic-は] passengers [possessive-の] safety [toward-に対し] responsibility [subject-が] exists.

に対し is a shortened form of に対して (toward/regarding) — common in formal written Japanese. 旅客機 (passenger plane) is a transparent compound: 旅客 (traveler/passenger) + 機 (machine). 責任がある (to have responsibility) is the standard expression for accountability.