Disruption of female hormone secretion is a major cause of infertility.
Literal
Female-hormone secretion [possessive-の] disruption [subject-が] infertility [possessive-の] large cause is.
A straightforward medical statement. 女性ホルモン分泌の乱れ chains multiple の-linked nouns: 'disruption of secretion of female hormones.' 不妊症 (infertility) is a medical compound. The sentence is a simple topic-comment structure with no hedging.