、。
The gate that leads to destruction is wide, and the road is broad.
Literal
Destruction [to-に] reach gate [topic-は] is-wide-[and-く], its road [topic-は] is-broad.
A direct translation of Matthew 7:13 ('wide is the gate, and broad is the way, that leadeth to destruction'). 滅び ('destruction, ruin') is the noun form of 滅びる ('to perish, be ruined'). 至る ('to reach, to arrive at') is a formal/literary verb for 'leading to.' 大きく is the adverbial/conjunctive form of 大きい ('big'), used here as a mid-sentence joiner.