。
I'm sick and tired of this monotonous daily life.
Literal
Every-day [possessive-の] monotonous life [topic-には] fed-up.
うんざり is a 擬態語 (state mimetic) expressing deep psychological exhaustion or disgust. には stacks に (target of the emotion) with は (topicalizing). 単調な ('monotonous') is a na-adjective. 暮らし ('living/lifestyle') has a warmer, more personal feel than the near-synonym 生活.