I'm thoroughly tired of the same old daily routine work.
Literal
Every-day [possessive-の] routine work [topic-には] thoroughly got-tired-of.
きまり仕事 ('routine work') is a compound — きまり ('set pattern') + 仕事 ('work'). つくづく is an adverb meaning 'thoroughly, deeply, keenly,' intensifying the exhaustion. 飽きた ('got tired of') takes には for the thing one is tired of.