My younger sister is 3 years younger and my brother is 4 years younger.

Literal

Younger-sister [topic-は] 3-years younger-and younger-brother [topic-は] 4-years younger.

年下 ('younger by X years') is the standard way to express relative age — X歳年下 ('X years younger'). で links the two clauses coordinately. The sentence efficiently packs two family facts into one statement.