Nothing good comes from getting involved with drugs.
Literal
Drugs [target-に] hand [object-を] put-out [conditional-と] decent thing [topic-は] not-exist.
手を出す ('to put one's hand out' = 'to get involved with, to mess with') is an idiomatic expression for dabbling in something risky. ろくなことはない ('nothing decent/good') uses ろく(な) — a word that appears almost exclusively in negative contexts.