。
Let's get to the point and talk about work.
Literal
Main-topic [target-に] enter-[sequential-て] work [attributive-の] talk [object-を] do-[volitional-よう].
Two clauses joined by the ~て-form: 本題に入って ('enter the main topic') + 仕事の話をしよう ('let's do work-talk'). The ~て form sequentially chains actions. 話をする ('to talk, have a conversation,' literally 'to do talk') is the standard light-verb construction for verbal interaction — Japanese often uses noun + する where English uses a simple verb.