I tried commuting by bicycle, but in the end it didn't suit me.
Literal
I [topic-は] bicycle [by-で] commuting [object-を] attempted [but-が] finally this [topic-は] nature [to-に] did-not-match.
試みる (こころみる, 'to attempt') — more literary than 試す. 性に合う (しょうにあう) is an idiom meaning 'to suit one's temperament' — 性 here is 'nature, disposition.' ついに ('finally, in the end') marks the conclusion after sustained effort.