No matter what I do, I have bad luck.

Literal

I [topic-は] what [object-を] do-[even-ても] bad-luck [subject-が] strong [explanatory-んだ].

何をやっても ('no matter what I do') uses the ~ても concessive form. 悪運が強い ('have strong bad luck') is an interesting expression — 強い ('strong') with bad luck. んだ provides explanatory framing.