。
In my opinion, he's not right for that job.
Literal
I [of-の] opinion [in-では], he [topic-は] that job [for-には] not-suited-is.
僕の意見では ('in my opinion') is a standard hedge for offering a viewpoint — で marks the frame ('in the frame of my opinion'), and は contrasts with implicit other viewpoints. 向く ('to face, to be suited to') in the ~ている state marks an ongoing suitability or its absence. に+は marks the thing one is/isn't suited for with contrastive emphasis.