。
You're from Hokkaido, right?
Literal
Hokkaido [of-の] [honorific-御-]origin is [confirmation-よね].
御出身 uses the prefix ご- on 出身 ('origin, birthplace'), making it a polite question about someone else. 北海道の御出身 = 'of Hokkaido origin.' The よね ending confirms an existing belief — 'you're [X], right?' A polite conversational opening at a first meeting.