。
I can't attend the party because I'm busy.
Literal
Busy [because-ので] party [to-には] can't-attend.
ので gives a polite reason. には combines the directional に with contrastive は — 'as for the party (in particular), I can't attend.' 出られません is the polite potential negative of 出る (to attend/appear). The は subtly implies the speaker might be available for other things, just not this.