Mother looked up from the newspaper and looked at me.

Literal

Mother [topic-は], newspaper [from-から] eyes [obj-を] raised and me [obj-を] looked-at.

目を上げる ('raise the eyes') is a common body-part idiom for 'look up (from what one was looking at)' — similar constructions include 首を傾げる (tilt the head), 肩を落とす (droop the shoulders). から marks the source point of the gaze-shift. The te-form chains the two visual actions — raising the eyes and then directing them at the speaker.