Things [object-を] do [purpose-に] [topic-は], how-much be-careful also do-too-much [nominalizer-こと] [topic-は] not-exist.
いくら注意してもし過ぎることはない means 'no matter how careful you are, it's never too much.' いくら...ても is 'no matter how much.' し過ぎる means 'to overdo.' A proverb-like expression of caution.